Guide Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

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Cellular differentiation

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The emerging role of epigenetics in human autoimmune disorders | Clinical Epigenetics | Full Text

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia. Eur J Haematol ; 81 : — A deeper exploration of the complex epigenetic interactions may be useful for the development of promising treatment strategies targeting the epigenome.

The fundamental work of Farh et al. However, to date, there is still a lot of research necessary in order to provide effective healthcare solutions for such diseases, such as an adequate choice of treatment and a precise prediction of treatment outcomes. Epigenetics will very likely aid to provide further progress in the field of autoimmunity. Until now, only a few studies have been carried out to examine the clinical applicability of epigenetics and its modulators in such autoimmune diseases.

Keeping this concept in mind, more comprehensive and more accessible technologies are recommended to promote advances in the therapeutics leading to prevention by early interventions and reducing both costs and patient morbidity. Taken together, the future of epigenetics in autoimmunity is rapidly increasing. However, it still needs an in-depth investigation to allow novel potential therapeutic opportunities, better than those currently used. Bird A.

Epigenetics - An Introduction

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